Atrial Fibrillation and Dementia: How an Irregular Heartbeat Affects the Brain
Atrial fibrillation (AFib) is linked to a higher risk of memory problems and dementia, partly through stroke. Here's what the research shows, what's still unknown, and questions to ask the doctor.
Short answer: atrial fibrillation (AFib), a common irregular heartbeat, is linked to a higher risk of memory problems and dementia. A 2013 review of 21 studies found about a 40% higher risk of cognitive impairment, even in people who hadn't had a stroke. Experts say it isn't proven that AFib directly causes dementia. Blood thinners lower stroke risk, and one study linked them to lower dementia risk. Talk to your doctor about managing AFib.
If you or someone you love has AFib, you've probably heard a lot about stroke. You may not have heard that AFib is also linked to memory and thinking problems.
Here's what the research says, and what it doesn't.
This page is general information, not medical advice. Never start, stop or change a blood thinner or heart medicine without talking to your doctor.
What is atrial fibrillation?
The NHS describes atrial fibrillation as a heart rhythm problem where your heartbeat is not steady. Symptoms can include:
- An irregular pulse
- A heart that feels like it's pounding, racing, fluttering or skipping beats (palpitations)
- Feeling very tired, short of breath, lightheaded or dizzy
- Finding it harder to exercise
- Chest pain or tightness
Sometimes there are no symptoms at all, and AFib is found during a routine check-up.
Call 911 if someone has a fast or irregular heartbeat with chest pain, fainting, weakness or numbness on one side, trouble speaking, sudden confusion or vision loss. These can be signs of a heart attack or stroke.
What the research shows
A higher risk of memory problems. A 2013 meta-analysis in the Annals of Internal Medicine pooled 21 studies. AFib was linked to a much higher risk of cognitive impairment in people who had had a stroke (about 2.7 times the risk). In the broader population, with or without a history of stroke, AFib was linked to about a 40% higher risk. The link held even after accounting for stroke history. The authors noted the studies were observational and varied a lot.
Faster decline and more vascular dementia. A 2018 Swedish study in Neurology followed 2,685 older adults for about nine years. AFib was linked to faster decline on a memory and thinking test and a 40% higher risk of dementia overall. The link was strongest for vascular and mixed dementia. It was not statistically significant for Alzheimer's disease alone. See Vascular Dementia and Mixed Dementia.
Blood thinners. In that same study, people with AFib who took anticoagulant (blood-thinning) medicines had a 60% lower risk of dementia than those who didn't. Antiplatelet drugs such as aspirin didn't show this link. The Alzheimer's Society said the study added weight to the link between heart health, stroke and vascular dementia. Because this was an observational study, it can't prove the medicines caused the lower risk.
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Why might AFib affect the brain?
A 2022 expert report from the AF-SCREEN International Collaboration, published in Circulation, reviewed the evidence. It said AFib and dementia share many risk factors, but the link appears to be independent of them. It listed several possible explanations:
- Strokes, including tiny "silent" strokes (microinfarcts) that may not cause obvious symptoms. See Memory Loss After a Stroke: What to Expect and How to Help.
- Reduced blood flow to the brain from an irregular heartbeat.
- Inflammation.
- Small bleeds in the brain.
- Brain shrinkage and hardening of the arteries.
The report was clear that the evidence is still inconclusive about whether AFib directly causes dementia. It also said it's unknown whether controlling heart rhythm versus heart rate makes a difference to the brain, and that screening for AFib to prevent dementia is still debated.
What this means for you
There's no proven way to prevent dementia in people with AFib yet. But AFib is very treatable, and treating it well protects against stroke, which is a major cause of memory loss.
The NHS says treatment may include medicines to control heart rate and rhythm, such as beta blockers, and anticoagulants to lower the risk of blood clots and stroke. Other options include ablation, cardioversion or a pacemaker. Your doctor will weigh your stroke risk and bleeding risk.
Things you can do:
- Take medicines as prescribed. If side effects worry you, talk to your doctor or pharmacist. Don't stop on your own.
- Keep regular check-ups. The NHS says people with AFib should have regular check-ups to make sure symptoms are controlled.
- Look after your heart and blood vessels. Blood pressure, diabetes, smoking and inactivity matter for both heart and brain. See Blood Pressure and the Brain and Reducing Dementia Risk: The 14 Risk Factors.
- Mention memory changes. If you notice new forgetfulness or confusion, tell your doctor. The AF-SCREEN report suggested cognition should get more attention in people with AFib.
Questions to ask the doctor
- Is my stroke risk high enough that I should be on a blood thinner?
- Is my heart rate and rhythm well controlled?
- Could any of my heart medicines affect my memory or energy?
- Should my memory be checked, given my AFib?
- What else can I do to lower my risk of stroke?
For tips on getting the most from appointments, see Preparing for a Memory Appointment.
Common questions
Does atrial fibrillation cause dementia?
It's linked to a higher risk, but experts say it isn't proven to cause dementia directly. A 2013 review found about a 40% higher risk of cognitive impairment, and a 2022 expert report called the evidence for a direct cause inconclusive.
Can blood thinners lower dementia risk in AFib?
A 2018 Swedish study found people with AFib on anticoagulants had a 60% lower risk of dementia. This was observational, so it doesn't prove cause. Blood thinners are prescribed mainly to prevent stroke. Your doctor will decide if they're right for you.
Is AFib linked to Alzheimer's or vascular dementia?
In the 2018 Swedish study, the link was strongest for vascular and mixed dementia, and wasn't statistically significant for Alzheimer's disease alone. Other studies differ, and researchers say more work is needed.
What are the warning signs of AFib?
The NHS lists an irregular pulse, palpitations, tiredness, breathlessness, dizziness and chest tightness. Some people have no symptoms. See a doctor if you notice them, and call 911 for chest pain, fainting or stroke signs.
The bottom line
AFib is linked to a higher risk of memory problems and dementia, likely in part through stroke. It's not proven to be a direct cause. Getting AFib diagnosed and well treated, keeping up with check-ups and caring for your heart are good for your brain too.
Sources
- NHS: Atrial fibrillation
- Alzheimer's Society: People with irregular heartbeat at greater risk of dementia (comment, 2018)
- Annals of Internal Medicine (2013): Kalantarian S et al., Cognitive impairment associated with atrial fibrillation: a meta-analysis (PubMed 23460057)
- Neurology (2018): Ding M et al., Atrial fibrillation, antithrombotic treatment, and cognitive aging: a population-based study (PubMed 30305443)
- Circulation (2022): Rivard L et al., Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration (PubMed 35100023)
Not medical advice. This article is general information, not a diagnosis or treatment plan for any individual. Talk with a doctor about your situation.
Related articles
- Vascular Dementia
- Memory Loss After a Stroke: What to Expect and How to Help
- Blood Pressure and the Brain
- Reducing Dementia Risk: The 14 Risk Factors
- White Matter Disease on a Brain Scan: What It Means
- Mixed Dementia
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